Endocrine Abstracts

Background: Several ultrasound (US) scoring systems have been proposed to provide rules for standardizing risk stratification of thyroid nodules and to select which nodules should have a fine needle aspiration (FNA) biopsy performed. TI-RADS classification is one of the most used in the daily practise. Recently, EU-TIRADS scoring system has been published to simplify the evaluation of thyroid nodules and to integrate previous classifications into a single system. We aimed to c...

Introduction: Visceral adipose tissue (VAT) is the key target tissue of glucocorticoids (GC) during active Cushing Syndrome (CS) and a metabolic tissue associated to insulin-resistance and an increased cardiometabolic risk. Till date there are no data regarding gene expression in VAT in CS and only few data about the mRNA in subcutaneous one. The aim of this study was to study the visceral VAT tissue transcriptional changes in ACTH-independent CS.Methods...

Introduction: Clinical observational studies have reported the persistence of a high cardiovascular risk in patients with cured Cushing’s syndrome (CCS) compared with controls of the same age, gender and BMI. It is still at debated whether this is due to the persistence of comorbidities, hormone deficiencies or chronic changes induced by hypercortisolism. The aim of this translational approach was to investigate the interplay in CCS of the cardiovascular disease in vivo a...

Introduction: Chronic hypercortisolemia during Cushing Syndrome (CS) determines significant changes in the plasticity and function of metabolic tissues like visceral adipose tissue (VAT). Persistence of alterations in VAT function after CS remission is under debate, as data of clinical studies is not consistent due to confounder factors and limited availability of VAT. Animal model of reversible CS presents long-term alterations on VAT after remission. We investigate VAT alter...